Homo sapiens Gene: WRNIP1
InnateDB Gene IDBG-56442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WRNIP1
Gene Name Werner helicase interacting protein 1
Species Homo sapiens
Ensembl Gene ENSG00000124535
Encoded Proteins
Werner helicase interacting protein 1
Werner helicase interacting protein 1
Werner helicase interacting protein 1
Werner helicase interacting protein 1
Werner helicase interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:2765414-2786952
Strand Forward strand
Band p25.2
ENST00000380773 ENSP00000370150
ENST00000380771 ENSP00000370148
ENST00000380769 ENSP00000370146
ENST00000380764 ENSP00000370141
ENST00000618555 ENSP00000477551
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0030174 regulation of DNA-dependent DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q96S55
UniProt Splice Variant
Entrez Gene 56897
UniGene Hs.236828
RefSeq NM_020135 NM_130395 XM_005249232
OMIM 608196
HPRD 10494
EMBL AB056152 AB209723 AF218313 AK026179 AK223593 AK315471 AL139092 BC018923 CH471087
GenPept AAF80563 AAH18923 BAB15383 BAB60709 BAD92960 BAD97313 BAG37857 CAH73663 CAH73664 CAH73665 CAH73666 EAW55087
RNA Seq Atlas 56897