Homo sapiens Gene: DROSHA
Summary
InnateDB Gene IDBG-14255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DROSHA
Gene Name drosha, ribonuclease type III
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113360
Encoded Proteins
drosha, ribonuclease type III
drosha, ribonuclease type III
drosha, ribonuclease type III
drosha, ribonuclease type III
drosha, ribonuclease type III
drosha, ribonuclease type III
drosha, ribonuclease type III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:31400497-31532196
Strand Reverse strand
Band p13.3
Transcripts
ENST00000344624 ENSP00000339845
ENST00000442743 ENSP00000409335
ENST00000511367 ENSP00000425979
ENST00000513349 ENSP00000424161
ENST00000514927
ENST00000511778
ENST00000512166
ENST00000509067
ENST00000504133
ENST00000510178
ENST00000505601
ENST00000507174
ENST00000509608
ENST00000512124
ENST00000511803
ENST00000510375
ENST00000512885
ENST00000512076 ENSP00000422745
ENST00000512302 ENSP00000428782
ENST00000507438 ENSP00000430921
ENST00000504361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 54 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003723 RNA binding
GO:0004521 endoribonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010586 miRNA metabolic process
GO:0016075 rRNA catabolic process
GO:0031053 primary miRNA processing
GO:0031054 pre-miRNA processing
GO:0042254 ribosome biogenesis
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.97997
RefSeq NM_001100412 NM_013235 XM_005248291
HUGO
OMIM
CCDS CCDS47194 CCDS47195
HPRD 10196
IMGT
EMBL
GenPept
RNA Seq Atlas