InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DROSHA

Summary

InnateDB Gene

IDBG-14255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DROSHA

Gene Name

drosha, ribonuclease type III

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000113360

Encoded Proteins

IDBP-14257

drosha, ribonuclease type III

IDBP-363343

drosha, ribonuclease type III

IDBP-476863

drosha, ribonuclease type III

IDBP-473569

drosha, ribonuclease type III

IDBP-483385

drosha, ribonuclease type III

IDBP-474862

drosha, ribonuclease type III

IDBP-480938

drosha, ribonuclease type III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:31400497-31532196

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000344624	ENSP00000339845
ENST00000442743	ENSP00000409335
ENST00000511367	ENSP00000425979
ENST00000513349	ENSP00000424161
ENST00000514927
ENST00000511778
ENST00000512166
ENST00000509067
ENST00000504133
ENST00000510178
ENST00000505601
ENST00000507174
ENST00000509608
ENST00000512124
ENST00000511803
ENST00000510375
ENST00000512885
ENST00000512076	ENSP00000422745
ENST00000512302	ENSP00000428782
ENST00000507438	ENSP00000430921
ENST00000504361

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	54 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006396	RNA processing
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0010586	miRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0031053	primary miRNA processing
GO:0031054	pre-miRNA processing
GO:0042254	ribosome biogenesis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022191

View Gene Order

ENSBTAG00000017551

Not yet available

Pathways

NETPATH

REACTOME

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_71

Gene Expression pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.97997

RefSeq

NM_001100412 NM_013235 XM_005248291

HUGO

OMIM

CCDS

CCDS47194 CCDS47195

HPRD

10196

IMGT

EMBL

GenPept

RNA Seq Atlas