InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fth1

Summary

InnateDB Gene

IDBG-142805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fth1

Gene Name

ferritin heavy chain 1

Synonyms

FHC; Fth; HFt; MFH

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024661

Encoded Proteins

IDBP-142807

ferritin heavy chain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167996:
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:9982703-9985092

Strand

Forward strand

Band

Transcripts

ENSMUST00000025563

ENSMUSP00000025563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0055114	oxidation-reduction process