Version 5.4
| Mus musculus Gene: Gne | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-143173.7 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | Gne | ||||||||||||||||
| Gene Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | ||||||||||||||||
| Synonyms | 2310066H07Rik; DMRV; GLCNE; IBM2; NM; Uae1 | ||||||||||||||||
| Species | Mus musculus | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000028479 | ||||||||||||||||
| Encoded Proteins |
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
glucosamine
|
||||||||||||||||
| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159921:
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
||||||||||||||||
| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 4:44034075-44084177 | ||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||
| Band | B1 | ||||||||||||||||
| Transcripts | |||||||||||||||||
| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||
| Gene Ontology | |||||||||||||||||
Molecular Function |
|
||||||||||||||||
| Biological Process |
|
||||||||||||||||
| Cellular Component |
|
||||||||||||||||
| Orthologs | |||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||
| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Synthesis of substrates in N-glycan biosythesis pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
|
||||||||||||||||
| KEGG |
Amino sugar and nucleotide sugar metabolism pathway
|
||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
|
||||||||||||||||
| KEGG |
Amino sugar and nucleotide sugar metabolism pathway
|
||||||||||||||||
| INOH |
Aminosugars metabolism pathway
|
||||||||||||||||
| PID NCI | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | |||||||||||||||||
| UniGene | Mm.256718 Mm.480800 | ||||||||||||||||
| RefSeq | NM_001190414 NM_015828 XM_006538073 XM_006538074 XM_006538075 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | CCDS18120 CCDS51170 | ||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| MGI ID | |||||||||||||||||
| MGI Symbol | |||||||||||||||||
| EMBL | |||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||