InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gne

Summary

InnateDB Protein

IDBP-143177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gne

Protein Name

glucosamine

Synonyms

2310066H07Rik; DMRV; GLCNE; IBM2; NM; Uae1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100000

InnateDB Gene

IDBG-143173 (Gne)

Protein Structure

UniProt Annotation

Function

Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells (By similarity). Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development. {ECO:0000250, ECO:0000269PubMed:11929971}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highest expression in liver. Also found at high levels in lung, brain and kidney. {ECO:0000269PubMed:10103025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity
GO:0009384	N-acylmannosamine kinase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006045	N-acetylglucosamine biosynthetic process
GO:0006047	UDP-N-acetylglucosamine metabolic process
GO:0006054	N-acetylneuraminate metabolic process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0046380	N-acetylneuraminate biosynthetic process
GO:0046835	carbohydrate phosphorylation