Mus musculus Gene: Foxo1
Summary
InnateDB Gene IDBG-143370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxo1
Gene Name forkhead box O1
Synonyms Afxh; AI876417; FKHR; Fkhr1; Foxo1a;
Species Mus musculus
Ensembl Gene ENSMUSG00000044167
Encoded Proteins
forkhead box O1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150907:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:52268337-52350109
Strand Forward strand
Band C
Transcripts
ENSMUST00000053764 ENSMUSP00000055308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 26 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0031625 ubiquitin protein ligase binding
GO:0043565 sequence-specific DNA binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007389 pattern specification process
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0009888 tissue development
GO:0010508 positive regulation of autophagy
GO:0031018 endocrine pancreas development
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0042127 regulation of cell proliferation
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071455 cellular response to hyperoxia
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
AKT-mediated inactivation of FOXO1A pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Regulation of gene expression in beta cells pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
GAB1 signalosome pathway
Regulation of beta-cell development pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Insulin signaling pathway pathway
Pathways in cancer pathway
Prostate cancer pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
BCR pathway
IL3 pathway
IL6 pathway
IL-7 pathway
Leptin pathway
FSH pathway
REACTOME
AKT-mediated inactivation of FOXO1A pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of beta-cell development pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Regulation of gene expression in beta cells pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
DAP12 interactions pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
Regulation of gene expression in early pancreatic precursor cells pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
AKT-mediated inactivation of FOXO1A pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by FGFR pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Regulation of gene expression in beta cells pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
Regulation of beta-cell development pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
Developmental Biology pathway
KEGG
Insulin signaling pathway pathway
Pathways in cancer pathway
Prostate cancer pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
Akt signaling pathway [Biocarta view]
PID NCI
CXCR4-mediated signaling events
FoxO family signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by HDAC Class III
Regulation of Androgen receptor activity
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29891 Mm.403212 Mm.408547
RefSeq NM_019739
OMIM
CCDS CCDS17343
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas