Homo sapiens Gene: GCK
Summary
InnateDB Gene IDBG-14358.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCK
Gene Name glucokinase (hexokinase 4)
Synonyms FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2;
Species Homo sapiens
Ensembl Gene ENSG00000106633
Encoded Proteins
glucokinase (hexokinase 4)
glucokinase (hexokinase 4)
glucokinase (hexokinase 4)
glucokinase (hexokinase 4)
glucokinase (hexokinase 4)
glucokinase (hexokinase 4)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44144271-44198170
Strand Reverse strand
Band p13
Transcripts
ENST00000336642 ENSP00000338009
ENST00000345378 ENSP00000223366
ENST00000395796 ENSP00000379142
ENST00000403799 ENSP00000384247
ENST00000437084 ENSP00000402840
ENST00000459642
ENST00000473353
ENST00000476008
ENST00000616242 ENSP00000482149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019903 protein phosphatase binding
GO:0043531 ADP binding
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006110 regulation of glycolytic process
GO:0006739 NADP metabolic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008645 hexose transport
GO:0009749 response to glucose
GO:0010827 regulation of glucose transport
GO:0015758 glucose transport
GO:0016310 phosphorylation
GO:0019932 second-messenger-mediated signaling
GO:0031018 endocrine pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0032811 negative regulation of epinephrine secretion
GO:0032869 cellular response to insulin stimulus
GO:0042149 cellular response to glucose starvation
GO:0042327 positive regulation of phosphorylation
GO:0042593 glucose homeostasis
GO:0043266 regulation of potassium ion transport
GO:0044281 small molecule metabolic process
GO:0044320 cellular response to leptin stimulus
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0046835 carbohydrate phosphorylation
GO:0050796 regulation of insulin secretion
GO:0051156 glucose 6-phosphate metabolic process
GO:0051594 detection of glucose
GO:0055085 transmembrane transport
GO:0055088 lipid homeostasis
GO:0070509 calcium ion import
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005938 cell cortex
GO:0030141 secretory granule
GO:0045180 basal cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Myoclonic epilepsy of Lafora pathway
Glucose transport pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Regulation of beta-cell development pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
Regulation of gene expression in beta cells pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Galactose metabolism pathway
Starch and sucrose metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
Butirosin and neomycin biosynthesis pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
INOH
Fructose Mannose metabolism pathway
Glycolysis Gluconeogenesis pathway
Aminosugars metabolism pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1270
RefSeq NM_000162 NM_033507 NM_033508
HUGO
OMIM
CCDS CCDS5479 CCDS5480 CCDS5481
HPRD 00680
IMGT
EMBL
GenPept
RNA Seq Atlas