Homo sapiens Gene: LIAS
Summary
InnateDB Gene IDBG-14368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIAS
Gene Name lipoic acid synthetase
Synonyms LAS; LIP1; LS; PDHLD;
Species Homo sapiens
Ensembl Gene ENSG00000121897
Encoded Proteins
lipoic acid synthetase
lipoic acid synthetase
lipoic acid synthetase
lipoic acid synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39459000-39477653
Strand Forward strand
Band p14
Transcripts
ENST00000261434 ENSP00000261434
ENST00000340169 ENSP00000340676
ENST00000381846 ENSP00000371270
ENST00000424936
ENST00000509519
ENST00000513731 ENSP00000425580
ENST00000515061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016992 lipoate synthase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0001843 neural tube closure
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0009107 lipoate biosynthetic process
GO:0009249 protein lipoylation
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lipoic acid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43766
TrEMBL A0A024R9W0 D6RCP8
UniProt Splice Variant
Entrez Gene 11019
UniGene Hs.550502
RefSeq NM_001278590 NM_006859 NM_194451
HUGO HGNC:16429
OMIM 607031
CCDS CCDS3453 CCDS3454 CCDS63950
HPRD
IMGT
EMBL AC021148 AJ224162 AK292238 BC023635 CH471069
GenPept AAH23635 BAF84927 CAA11859 EAW92932 EAW92934
RNA Seq Atlas 11019