Version 5.4
Homo sapiens Protein: LIAS
Summary
InnateDB Protein IDBP-14374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIAS
Protein Name lipoic acid synthetase
Synonyms LAS; LIP1; LS; PDHLD;
Species Homo sapiens
Ensembl Protein ENSP00000340676
InnateDB Gene IDBG-14368 (LIAS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016992 lipoate synthase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0009107 lipoate biosynthetic process
GO:0009249 protein lipoylation
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR003698 Lipoyl synthase
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM
PFAM PF04055
PRINTS
PIRSF PIRSF005963
SMART SM00729
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43766
PhosphoSite PhosphoSite-O43766
TrEMBL
UniProt Splice Variant
Entrez Gene 11019
UniGene Hs.550502
RefSeq NP_919433
HUGO HGNC:16429
OMIM 607031
CCDS CCDS3454
HPRD 09514
IMGT
EMBL AC021148 AJ224162 AK292238 BC023635 CH471069
GenPept AAH23635 BAF84927 CAA11859 EAW92932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca