Mus musculus Gene: Dpysl3
Summary
InnateDB Gene IDBG-143786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpysl3
Gene Name dihydropyrimidinase-like 3
Synonyms CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1;
Species Mus musculus
Ensembl Gene ENSMUSG00000024501
Encoded Proteins
dihydropyrimidinase-like 3
dihydropyrimidinase-like 3
dihydropyrimidinase-like 3
dihydropyrimidinase-like 3
dihydropyrimidinase-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:43320979-43438286
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000025379 ENSMUSP00000025379
ENSMUST00000121805 ENSMUSP00000112928
ENSMUST00000118043 ENSMUSP00000113711
ENSMUST00000118071 ENSMUSP00000113604
ENSMUST00000135547
ENSMUST00000124207 ENSMUSP00000114981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0017124 SH3 domain binding
GO:0035374 chondroitin sulfate binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0030336 negative regulation of cell migration
GO:0048666 neuron development
GO:0048678 response to axon injury
GO:0051017 actin filament bundle assembly
GO:0051260 protein homooligomerization
GO:0051491 positive regulation of filopodium assembly
GO:0051764 actin crosslink formation
GO:0071345 cellular response to cytokine stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0031941 filamentous actin
GO:0044297 cell body
GO:0070382 exocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
CRMPs in Sema3A signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.393249 Mm.409796 Mm.428551 Mm.473439 Mm.8180
RefSeq NM_001136086 NM_001291455 NM_009468
OMIM
CCDS CCDS37801 CCDS50269
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas