Version 5.4
Mus musculus Gene: Spink3
Summary
InnateDB Gene IDBG-144006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spink3
Gene Name serine peptidase inhibitor, Kazal type 3
Synonyms p12
Species Mus musculus
Ensembl Gene ENSMUSG00000024503
Encoded Proteins
IDBP-144008
serine peptidase inhibitor, Kazal type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164266:
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:43728069-43737237
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000025381 ENSMUSP00000025381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046 regulation of acrosome reaction
GO:0090281 negative regulation of calcium ion import
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000164266
View Gene Order
Cross-References
SwissProt P09036
TrEMBL
UniProt Splice Variant
Entrez Gene 20730
UniGene
RefSeq NM_009258
OMIM
CCDS CCDS37803
HPRD
IMGT
MGI ID MGI:106202
MGI Symbol Spink3
EMBL AK007841 AK007985 BC086887 X06342
GenPept AAH86887 BAB25298 BAB25389 CAA29648
RNA Seq Atlas 20730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca