Version 5.4
Homo sapiens Gene: SPINK1
Summary
InnateDB Gene IDBG-52280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK1
Gene Name serine peptidase inhibitor, Kazal type 1
Synonyms PCTT; PSTI; Spink3; TATI; TCP
Species Homo sapiens
Ensembl Gene ENSG00000164266
Encoded Proteins
IDBP-52282
serine peptidase inhibitor, Kazal type 1
IDBP-473708
serine peptidase inhibitor, Kazal type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:147824568-147831786
Strand Reverse strand
Band q32
Transcripts
ENST00000296695 ENSP00000296695
ENST00000505722
ENST00000510027 ENSP00000427376
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046 regulation of acrosome reaction
GO:0090281 negative regulation of calcium ion import
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024503
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003122 XM_005268501
HUGO
OMIM
CCDS CCDS4286
HPRD 01341
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca