Mus musculus Gene: Ube2m
Summary
InnateDB Gene IDBG-144148.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2m
Gene Name ubiquitin-conjugating enzyme E2M
Synonyms 2510040H03Rik; Ubc-rs2; UBC12;
Species Mus musculus
Ensembl Gene ENSMUSG00000005575
Encoded Proteins
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130725:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13035120-13038275
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000005714 ENSMUSP00000005714
ENSMUST00000131837
ENSMUST00000125964 ENSMUSP00000122638
ENSMUST00000123541 ENSMUSP00000120234
ENSMUST00000138357
ENSMUST00000156389 ENSMUSP00000117123
ENSMUST00000126827
ENSMUST00000165394 ENSMUSP00000132604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0018169 ribosomal S6-glutamic acid ligase activity
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
GO:0043525 positive regulation of neuron apoptotic process
GO:0045116 protein neddylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
TGF-beta receptor signaling activates SMADs pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt P61082
TrEMBL G5E919
UniProt Splice Variant
Entrez Gene 22192
UniGene
RefSeq NM_145578 NM_001168469 NM_001243968 XM_006539732
OMIM
CCDS CCDS20825 CCDS52024
HPRD
IMGT
MGI ID MGI:108278
MGI Symbol Ube2m
EMBL AC121301 BC021792 CH466634
GenPept AAH21792 EDL38075 EDL38076
RNA Seq Atlas 22192