InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2M

Summary

InnateDB Gene

IDBG-73507.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2M

Gene Name

ubiquitin-conjugating enzyme E2M

Synonyms

hUbc12; UBC-RS2; UBC12

Species

Homo sapiens

Ensembl Gene

ENSG00000130725

Encoded Proteins

IDBP-73509

ubiquitin-conjugating enzyme E2M

IDBP-760422

IDBP-759846

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:58555712-58558960

Strand

Reverse strand

Band

q13.43

Transcripts

ENST00000253023	ENSP00000253023
ENST00000595957	ENSP00000468940
ENST00000593801
ENST00000596985	ENSP00000469855
ENST00000599829

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	67 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0018169	ribosomal S6-glutamic acid ligase activity
GO:0019788	NEDD8 ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0043525	positive regulation of neuron apoptotic process
GO:0045116	protein neddylation