Homo sapiens Gene: UBE2M
Summary
InnateDB Gene IDBG-73507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2M
Gene Name ubiquitin-conjugating enzyme E2M
Synonyms hUbc12; UBC-RS2; UBC12;
Species Homo sapiens
Ensembl Gene ENSG00000130725
Encoded Proteins
ubiquitin-conjugating enzyme E2M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:58555712-58558960
Strand Reverse strand
Band q13.43
Transcripts
ENST00000253023 ENSP00000253023
ENST00000595957 ENSP00000468940
ENST00000593801
ENST00000596985 ENSP00000469855
ENST00000599829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 67 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0018169 ribosomal S6-glutamic acid ligase activity
GO:0019788 NEDD8 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
GO:0043525 positive regulation of neuron apoptotic process
GO:0045116 protein neddylation
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003969
HUGO
OMIM
CCDS CCDS12987
HPRD 04414
IMGT
EMBL
GenPept
RNA Seq Atlas