Homo sapiens Gene: CAMK2B
Summary
InnateDB Gene IDBG-14499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAMK2B
Gene Name calcium/calmodulin-dependent protein kinase II beta
Synonyms CAM2; CAMK2; CAMKB;
Species Homo sapiens
Ensembl Gene ENSG00000058404
Encoded Proteins
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase II beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44217150-44334577
Strand Reverse strand
Band p13
Transcripts
ENST00000258682 ENSP00000258682
ENST00000350811 ENSP00000326375
ENST00000353185 ENSP00000326600
ENST00000358707 ENSP00000351542
ENST00000347193 ENSP00000326544
ENST00000353625 ENSP00000326427
ENST00000346990 ENSP00000326518
ENST00000395749 ENSP00000379098
ENST00000395747 ENSP00000379096
ENST00000440254 ENSP00000397937
ENST00000457475 ENSP00000390292
ENST00000425809 ENSP00000410445
ENST00000433930 ENSP00000388951
ENST00000415369 ENSP00000390419
ENST00000424197 ENSP00000400387
ENST00000421607 ENSP00000388445
ENST00000427209
ENST00000523845 ENSP00000428912
ENST00000466584
ENST00000497584
ENST00000489429
ENST00000497127
ENST00000495819
ENST00000484972
ENST00000462128
ENST00000470984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002030 inhibitory G-protein coupled receptor phosphorylation
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0010976 positive regulation of neuron projection development
GO:0014733 regulation of skeletal muscle adaptation
GO:0018105 peptidyl-serine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0032222 regulation of synaptic transmission, cholinergic
GO:0046686 response to cadmium ion
GO:0046777 protein autophosphorylation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050885 neuromuscular process controlling balance
GO:0051823 regulation of synapse structural plasticity
GO:0051924 regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060466 activation of meiosis involved in egg activation
GO:0060998 regulation of dendritic spine development
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0090129 positive regulation of synapse maturation
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030666 endocytic vesicle membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Cellular responses to stress pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Immune System pathway
Trafficking of AMPA receptors pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Interferon gamma signaling pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
CREB phosphorylation through the activation of CaMKII pathway
KEGG
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Oocyte meiosis pathway
Wnt signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Olfactory transduction pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Gastric acid secretion pathway
Glioma pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Regulation of pgc-1a [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Bcr signaling pathway [Biocarta view]
Endocytotic role of ndk phosphins and dynamin [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Nitric oxide signaling pathway [Biocarta view]
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Ca-calmodulin-dependent protein kinase activation [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Signal dependent regulation of myogenesis by corepressor mitr [Biocarta view]
PID NCI
Regulation of Ras family activation
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.351887 Hs.732009
RefSeq NM_001220 NM_001293170 NM_172078 NM_172079 NM_172080 NM_172081 NM_172082 NM_172083 NM_172084 XM_006715776
HUGO
OMIM
CCDS CCDS43573 CCDS5483 CCDS5484 CCDS5485 CCDS5486 CCDS5487 CCDS5488 CCDS5489
HPRD 12127
IMGT
EMBL
GenPept
RNA Seq Atlas