InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dclk1

Summary

InnateDB Gene

IDBG-145412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dclk1

Gene Name

doublecortin-like kinase 1

Synonyms

1700113D08Rik; 2810480F11Rik; AI836758; Click-I; Cpg16; Dcamkl1; Dcl; Dclk; mKIAA0369

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027797

Encoded Proteins

IDBP-145414

doublecortin-like kinase 1

IDBP-145418

doublecortin-like kinase 1

IDBP-626035

doublecortin-like kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:55242526-55539064

Strand

Forward strand

Band

Transcripts

ENSMUST00000054237	ENSMUSP00000050034
ENSMUST00000070418	ENSMUSP00000070292
ENSMUST00000167204	ENSMUSP00000129334

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0009615	response to virus
GO:0016310	phosphorylation
GO:0021952	central nervous system projection neuron axonogenesis
GO:0030900	forebrain development
GO:0035556	intracellular signal transduction
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis

Cellular Component

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000133083

View Gene Order

Cross-References

SwissProt

Q9JLM8

TrEMBL

A3KN70

UniProt Splice Variant

Entrez Gene

13175

UniGene

Mm.393242 Mm.409147 Mm.470413 Mm.472264

RefSeq

NM_001195538 NM_019978 XM_006500980 XM_006500981 NM_001111051 NM_001111052 NM_001111053 NM_001195539 NM_001195540 XM_006500978 XM_006500979 XM_006500983

OMIM

CCDS

CCDS17359 CCDS50909 CCDS50910

HPRD

IMGT

MGI ID

MGI:1330861

MGI Symbol

Dclk1

EMBL

AF155819 BC064783 BC133685

GenPept

AAF26673 AAH64783 AAI33686

RNA Seq Atlas

13175