Mus musculus Gene: Dclk1
Summary
InnateDB Gene IDBG-145412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dclk1
Gene Name doublecortin-like kinase 1
Synonyms 1700113D08Rik; 2810480F11Rik; AI836758; Click-I; Cpg16; Dcamkl1; Dcl; Dclk; mKIAA0369;
Species Mus musculus
Ensembl Gene ENSMUSG00000027797
Encoded Proteins
doublecortin-like kinase 1
doublecortin-like kinase 1
doublecortin-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:55242526-55539064
Strand Forward strand
Band C
Transcripts
ENSMUST00000054237 ENSMUSP00000050034
ENSMUST00000070418 ENSMUSP00000070292
ENSMUST00000167204 ENSMUSP00000129334
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0009615 response to virus
GO:0016310 phosphorylation
GO:0021952 central nervous system projection neuron axonogenesis
GO:0030900 forebrain development
GO:0035556 intracellular signal transduction
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.393242 Mm.409147 Mm.470413 Mm.472264
RefSeq NM_001111051 NM_001111052 NM_001111053 NM_001195538 NM_001195539 NM_001195540 NM_019978 XM_006500978 XM_006500979 XM_006500980 XM_006500981 XM_006500983
OMIM
CCDS CCDS17359 CCDS50909 CCDS50910
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas