Mus musculus Gene: Ehd2
Summary
InnateDB Gene IDBG-145700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ehd2
Gene Name EH-domain containing 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000074364
Encoded Proteins
EH-domain containing 2
EH-domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000024422:
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:15946977-15967567
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000098799 ENSMUSP00000096397
ENSMUST00000144956 ENSMUSP00000119933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0030866 cortical actin cytoskeleton organization
GO:0032456 endocytic recycling
GO:0072659 protein localization to plasma membrane
GO:1901741 positive regulation of myoblast fusion
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Hemostasis pathway
Factors involved in megakaryocyte development and platelet production pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3Z7U7
UniProt Splice Variant
Entrez Gene 259300
UniGene Mm.138215 Mm.490293
RefSeq NM_153068
OMIM
CCDS CCDS20842
HPRD
IMGT
MGI ID MGI:2154274
MGI Symbol Ehd2
EMBL AC148990
GenPept
RNA Seq Atlas 259300