InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnk3

Summary

InnateDB Gene

IDBG-145858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnk3

Gene Name

potassium channel, subfamily K, member 3

Synonyms

cTBAK-1; TASK; Task-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049265

Encoded Proteins

IDBP-145862

potassium channel, subfamily K, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171303:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:30588170-30625270

Strand

Forward strand

Band

Transcripts

ENSMUST00000066295

ENSMUSP00000098987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005252	open rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0022841	potassium ion leak channel activity
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007420	brain development
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0071294	cellular response to zinc ion
GO:0071456	cellular response to hypoxia
GO:0071805	potassium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171303

View Gene Order

ENSBTAG00000018193

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_199084

Tandem pore domain potassium channels pathway

REACT_259290

Neuronal System pathway

REACT_199069

TWIK-releated acid-sensitive K+ channel (TASK) pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75899

TWIK-releated acid-sensitive K+ channel (TASK) pathway

REACT_75897

Tandem pore domain potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O35111

TrEMBL

UniProt Splice Variant

Entrez Gene

16527

UniGene

Mm.398059 Mm.439936

RefSeq

NM_010608

OMIM

CCDS

CCDS19160

HPRD

IMGT

MGI ID

MGI:1100509

MGI Symbol

Kcnk3

EMBL

AB008537 AB013345 AF006824 AF065162 AF241798 AF242508

GenPept

AAC53367 AAF81418 AAG29339 BAA25436 BAA28349

RNA Seq Atlas

16527