Mus musculus Gene: Kcnk3
Summary
InnateDB Gene IDBG-145858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnk3
Gene Name potassium channel, subfamily K, member 3
Synonyms cTBAK-1; TASK; Task-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000049265
Encoded Proteins
potassium channel, subfamily K, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171303:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:30588170-30625270
Strand Forward strand
Band B1
Transcripts
ENSMUST00000066295 ENSMUSP00000098987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005252 open rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0022841 potassium ion leak channel activity
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007420 brain development
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042493 response to drug
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0071294 cellular response to zinc ion
GO:0071456 cellular response to hypoxia
GO:0071805 potassium ion transmembrane transport
GO:0090102 cochlea development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Potassium Channels pathway
Tandem pore domain potassium channels pathway
Neuronal System pathway
TWIK-releated acid-sensitive K+ channel (TASK) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
TWIK-releated acid-sensitive K+ channel (TASK) pathway
Tandem pore domain potassium channels pathway
Neuronal System pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O35111
TrEMBL
UniProt Splice Variant
Entrez Gene 16527
UniGene Mm.398059 Mm.439936
RefSeq NM_010608
OMIM
CCDS CCDS19160
HPRD
IMGT
MGI ID MGI:1100509
MGI Symbol Kcnk3
EMBL AB008537 AB013345 AF006824 AF065162 AF241798 AF242508
GenPept AAC53367 AAF81418 AAG29339 BAA25436 BAA28349
RNA Seq Atlas 16527