Homo sapiens Gene: KCNK3
Summary
InnateDB Gene IDBG-35977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK3
Gene Name potassium channel, subfamily K, member 3
Synonyms K2p3.1; OAT1; PPH4; TASK; TASK-1; TBAK1;
Species Homo sapiens
Ensembl Gene ENSG00000171303
Encoded Proteins
potassium channel, subfamily K, member 3
potassium channel, subfamily K, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:26692690-26733420
Strand Forward strand
Band p23.3
Transcripts
ENST00000302909 ENSP00000306275
ENST00000620977 ENSP00000483136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005252 open rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0022841 potassium ion leak channel activity
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007420 brain development
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042493 response to drug
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0071294 cellular response to zinc ion
GO:0071456 cellular response to hypoxia
GO:0071805 potassium ion transmembrane transport
GO:0090102 cochlea development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
TWIK-releated acid-sensitive K+ channel (TASK) pathway
Tandem pore domain potassium channels pathway
Neuronal System pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14649
TrEMBL B9EIJ4
UniProt Splice Variant
Entrez Gene 3777
UniGene Hs.24040 Hs.645288
RefSeq NM_002246 XM_005264293
HUGO HGNC:6278
OMIM 603220
CCDS CCDS1727
HPRD
IMGT
EMBL AC015977 AF006823 AF065163 BC140701 CH471053
GenPept AAC51777 AAG29340 AAI40702 AAY24312 EAX00678 EAX00679
RNA Seq Atlas 3777