Version 5.4
| Mus musculus Gene: C8g | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-146088.6 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | C8g | ||||||||||||||
| Gene Name | complement component 8, gamma polypeptide | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Mus musculus | ||||||||||||||
| Ensembl Gene | ENSMUSG00000015083 | ||||||||||||||
| Encoded Proteins |
complement component 8, gamma polypeptide
complement component 8, gamma polypeptide
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||
| Summary |
[Homo sapiens] C8G is the gamma subunit of complement factor 8 (C8) and is one of five components that interact to form the membrane attack complex (MAC).
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| Entrez Gene | |||||||||||||||
| Summary |
This gene encodes a secreted protein that is a core component of the complement 8 (C8) complex. C8 is part of the membrane attack complex which participates in the innate immune response against bacterial pathogens. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 2:25498651-25501719 | ||||||||||||||
| Strand | Reverse strand | ||||||||||||||
| Band | A3 | ||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Innate Immune System pathway
Complement cascade pathway
Regulation of Complement cascade pathway
Immune System pathway
Terminal pathway of complement pathway
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| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Prion diseases pathway
Amoebiasis pathway
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| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Terminal pathway of complement pathway
Regulation of Complement cascade pathway
Innate Immune System pathway
Immune System pathway
Complement cascade pathway
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| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Prion diseases pathway
Amoebiasis pathway
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| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | Mm.24596 | ||||||||||||||
| RefSeq | NM_001271777 NM_027062 | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | CCDS15777 CCDS71001 | ||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| MGI ID | |||||||||||||||
| MGI Symbol | |||||||||||||||
| EMBL | |||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||