Version 5.4
Mus musculus Gene: Tg
Summary
InnateDB Gene IDBG-146348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tg
Gene Name thyroglobulin
Synonyms cog; Tgn
Species Mus musculus
Ensembl Gene ENSMUSG00000053469
Encoded Proteins
IDBP-146350
thyroglobulin
IDBP-622558
thyroglobulin
IDBP-622561
thyroglobulin
IDBP-622566
thyroglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000042832:
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:66670753-66850721
Strand Forward strand
Band D2
Transcripts
ENSMUST00000065916 ENSMUSP00000070239
ENSMUST00000163495 ENSMUSP00000129868
ENSMUST00000167512
ENSMUST00000171045 ENSMUSP00000126454
ENSMUST00000166906
ENSMUST00000167344
ENSMUST00000172153 ENSMUSP00000128410
ENSMUST00000166403
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0015705 iodide transport
GO:0030878 thyroid gland development
GO:0031641 regulation of myelination
GO:0042403 thyroid hormone metabolic process
GO:0042446 hormone biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000042832
View Gene Order
ENSBTAG00000007823
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
KEGG
hsa05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.441333
RefSeq NM_009375 XM_006520745
OMIM
CCDS CCDS37091
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca