InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tg

Summary

InnateDB Protein

IDBP-146350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

thyroglobulin

Synonyms

cog; Tgn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070239

InnateDB Gene

IDBG-146348 (Tg)

Protein Structure

UniProt Annotation

Function

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Subcellular Localization

Secreted.

Disease Associations

Note=Defects in Tg are the cause of some forms of goiter. Goiter is an enlargement of the thyroid gland. The variant Pro- 2283 exhibits a defect in exit from the endoplasmic reticulum.

Tissue Specificity

Thyroid gland specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0006590	thyroid hormone generation
GO:0015705	iodide transport
GO:0030878	thyroid gland development
GO:0031641	regulation of myelination
GO:0042403	thyroid hormone metabolic process
GO:0042446	hormone biosynthetic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:98733

InterPro

IPR000716 Thyroglobulin type-1
IPR002018 Carboxylesterase, type B
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR016324 Thyroglobulin
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00086
PF00135
PF07699

PRINTS

PIRSF

PIRSF001831

SMART

SM00211

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt