Mus musculus Gene: Gcnt2
Summary
InnateDB Gene IDBG-146446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcnt2
Gene Name glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms 5330430K10Rik; IGnT; IGnTA; IGnTB; IGnTC;
Species Mus musculus
Ensembl Gene ENSMUSG00000021360
Encoded Proteins
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111846:
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:40859768-40960891
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000069958 ENSMUSP00000070942
ENSMUST00000067778 ENSMUSP00000066467
ENSMUST00000110191 ENSMUSP00000105820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375 acetylglucosaminyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010608 posttranscriptional regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0030335 positive regulation of cell migration
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0036438 maintenance of lens transparency
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Glycosphingolipid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Glycosphingolipid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.314757 Mm.470743
RefSeq NM_008105 NM_023887 NM_133219
OMIM
CCDS CCDS26468 CCDS26469 CCDS36637
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas