InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gcnt2

Summary

InnateDB Gene

IDBG-146446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcnt2

Gene Name

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

Synonyms

5330430K10Rik; IGnT; IGnTA; IGnTB; IGnTC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021360

Encoded Proteins

IDBP-146448

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

IDBP-146450

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

IDBP-260821

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111846:
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:40859768-40960891

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000069958	ENSMUSP00000070942
ENSMUST00000067778	ENSMUSP00000066467
ENSMUST00000110191	ENSMUSP00000105820

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0010608	posttranscriptional regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010812	negative regulation of cell-substrate adhesion
GO:0030335	positive regulation of cell migration
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0036438	maintenance of lens transparency
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0000139	Golgi membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000111846

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu00601

Glycosphingolipid biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00601

Glycosphingolipid biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q3UJ01 Q7TPQ8

UniProt Splice Variant

Entrez Gene

14538

UniGene

Mm.314757 Mm.470743

RefSeq

NM_133219 NM_008105 NM_023887

OMIM

CCDS

CCDS26469 CCDS26468 CCDS36637

HPRD

IMGT

MGI ID

MGI:1100870

MGI Symbol

Gcnt2

EMBL

AC133496 AC159205 AK146679 AY435150 BC054845

GenPept

AAH54845 AAR95651 BAE27354

RNA Seq Atlas

14538