Version 5.4
Mus musculus Gene: Sncaip
Summary
InnateDB Gene IDBG-146777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sncaip
Gene Name synuclein, alpha interacting protein (synphilin)
Synonyms 2810407O15Rik; 4933427B05Rik; BB104594; SYPH1
Species Mus musculus
Ensembl Gene ENSMUSG00000024534
Encoded Proteins
IDBP-146779
synuclein, alpha interacting protein (synphilin)
IDBP-249713
synuclein, alpha interacting protein (synphilin)
IDBP-622703
synuclein, alpha interacting protein (synphilin)
IDBP-702572
IDBP-702690
IDBP-702614
IDBP-702652
IDBP-702705
IDBP-702630
IDBP-702770
IDBP-702610
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064692:
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson\'s disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:52767709-52915935
Strand Forward strand
Band D1
Transcripts
ENSMUST00000025413 ENSMUSP00000025413
ENSMUST00000115410 ENSMUSP00000111069
ENSMUST00000163742 ENSMUSP00000127189
ENSMUST00000177861 ENSMUSP00000136021
ENSMUST00000178678 ENSMUSP00000137367
ENSMUST00000178011 ENSMUSP00000137549
ENSMUST00000179625 ENSMUSP00000136838
ENSMUST00000180259 ENSMUSP00000137282
ENSMUST00000178883 ENSMUSP00000136200
ENSMUST00000179038 ENSMUSP00000137201
ENSMUST00000179689 ENSMUSP00000137107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
Biological Process
GO:0042417 dopamine metabolic process
GO:0046928 regulation of neurotransmitter secretion
GO:0090083 regulation of inclusion body assembly
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064692
View Gene Order
ENSBTAG00000021971
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05012
Parkinson's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q4E2 Q3V1N2
UniProt Splice Variant
Entrez Gene 67847
UniGene Mm.292168
RefSeq NM_026408 NM_001199151 NM_001199153 NM_001199154 XM_006526191 XM_006526192
OMIM
CCDS CCDS37820 CCDS57124
HPRD
IMGT
MGI ID MGI:1915097
MGI Symbol Sncaip
EMBL AC121943 AC124178 AK132346 CH466528
GenPept BAE21118 EDL09916
RNA Seq Atlas 67847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca