Version 5.4
Homo sapiens Gene: SNCAIP
Summary
InnateDB Gene IDBG-38780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCAIP
Gene Name synuclein, alpha interacting protein
Synonyms Sph1; SYPH1
Species Homo sapiens
Ensembl Gene ENSG00000064692
Encoded Proteins
IDBP-38782
synuclein, alpha interacting protein
IDBP-38784
synuclein, alpha interacting protein
IDBP-38786
synuclein, alpha interacting protein
IDBP-239471
synuclein, alpha interacting protein
IDBP-239473
synuclein, alpha interacting protein
IDBP-375269
synuclein, alpha interacting protein
IDBP-481911
synuclein, alpha interacting protein
IDBP-478576
synuclein, alpha interacting protein
IDBP-476598
synuclein, alpha interacting protein
IDBP-476536
synuclein, alpha interacting protein
IDBP-483573
synuclein, alpha interacting protein
IDBP-481836
synuclein, alpha interacting protein
IDBP-481707
synuclein, alpha interacting protein
IDBP-481259
synuclein, alpha interacting protein
IDBP-475688
synuclein, alpha interacting protein
IDBP-475768
synuclein, alpha interacting protein
IDBP-481046
synuclein, alpha interacting protein
IDBP-481045
synuclein, alpha interacting protein
IDBP-477311
synuclein, alpha interacting protein
IDBP-594313
synuclein, alpha interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson\'s disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122311354-122464219
Strand Forward strand
Band q23.2
Transcripts
ENST00000261368 ENSP00000261368
ENST00000379538 ENSP00000368854
ENST00000261367 ENSP00000261367
ENST00000395469 ENSP00000378852
ENST00000395466 ENSP00000378849
ENST00000414317 ENSP00000394392
ENST00000514467 ENSP00000427090
ENST00000510658 ENSP00000426526
ENST00000506272 ENSP00000426551
ENST00000508681 ENSP00000422610
ENST00000509154 ENSP00000422106
ENST00000512385 ENSP00000426280
ENST00000514497 ENSP00000425063
ENST00000510003
ENST00000509023 ENSP00000427078
ENST00000508017 ENSP00000424338
ENST00000509652 ENSP00000427587
ENST00000512146 ENSP00000423360
ENST00000504884 ENSP00000426904
ENST00000515215 ENSP00000427575
ENST00000513719
ENST00000542191 ENSP00000441681
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
Biological Process
GO:0008219 cell death
GO:0042417 dopamine metabolic process
GO:0046928 regulation of neurotransmitter secretion
GO:0090083 regulation of inclusion body assembly
Cellular Component
GO:0005737 cytoplasm
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024534
View Gene Order
ENSBTAG00000021971
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y6H5
TrEMBL
UniProt Splice Variant
Entrez Gene 9627
UniGene Hs.426463 Hs.740149
RefSeq NM_001242935 XM_006714737 NM_005460 XM_005272138 XM_005272139 XM_006714734 XM_006714735 XM_006714736 XM_006714738
HUGO HGNC:11139
OMIM 603779
CCDS CCDS58964 CCDS4131
HPRD 04804
IMGT
EMBL AB110788 AB110789 AB110790 AF076929 AF167301 AF167302 AF167303 AF167304 AF167305 AF167306 BC033743 BC040552 BC094759 CH471086 DQ227317
GenPept AAD30362 AAG17478 AAH33743 AAH40552 AAH94759 ABB51162 BAD19017 BAD19018 BAD19019 EAW48889 EAW48890
RNA Seq Atlas 9627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca