Mus musculus Gene: Aldob
Summary
InnateDB Gene IDBG-147038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldob
Gene Name aldolase B, fructose-bisphosphate
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028307
Encoded Proteins
aldolase B, fructose-bisphosphate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136872:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related \'housekeeping\' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5%% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:49535995-49549546
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000029987 ENSMUSP00000029987
ENSMUST00000148415
ENSMUST00000144372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0042802 identical protein binding
GO:0051117 ATPase binding
GO:0070061 fructose binding
Biological Process
GO:0006000 fructose metabolic process
GO:0006096 glycolytic process
GO:0006116 NADH oxidation
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0032781 positive regulation of ATPase activity
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly
Cellular Component
GO:0005815 microtubule organizing center
GO:0034451 centriolar satellite
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Disease pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Fructose catabolism pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Fructose catabolism pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
INOH
Fructose Mannose metabolism pathway
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt Q91Y97
TrEMBL Q3UER1
UniProt Splice Variant
Entrez Gene 230163
UniGene Mm.218862 Mm.482116 Mm.486174
RefSeq NM_144903
OMIM
CCDS CCDS18176
HPRD
IMGT
MGI ID MGI:87995
MGI Symbol Aldob
EMBL AF403565 AF403566 AF403567 AK135385 AK149395 AK149598 AK167334 AK168600 AK168997 BC016435 BC022113 BC024056 BC024112 BC026577 BC030724 BC030725 BC034169 BC034171 BC034172 BC034173 BC036130 BC036131 BC036132 BC036133 CH466565
GenPept AAH16435 AAH22113 AAH24056 AAH24112 AAH26577 AAH30724 AAH30725 AAH34169 AAH34171 AAH34172 AAH34173 AAH36130 AAH36131 AAH36132 AAH36133 AAL06323 BAE22514 BAE28850 BAE28983 BAE39436 BAE40467 BAE40796 EDL02311
RNA Seq Atlas 230163