Mus musculus Gene: Aldob | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-147038.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Aldob | ||||||||||||||||||||||
Gene Name | aldolase B, fructose-bisphosphate | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000028307 | ||||||||||||||||||||||
Encoded Proteins |
aldolase B, fructose-bisphosphate
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136872:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008] Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related \'housekeeping\' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5%% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 4:49535995-49549546 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Disease pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Fructose catabolism pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
|
||||||||||||||||||||||
KEGG |
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Glycolysis / Gluconeogenesis pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Fructose catabolism pathway
Glycolysis pathway
Gluconeogenesis pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
|
||||||||||||||||||||||
KEGG |
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
|
||||||||||||||||||||||
INOH |
Glycolysis Gluconeogenesis pathway
Fructose Mannose metabolism pathway
Pentose phosphate cycle pathway
|
||||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q91Y97 | ||||||||||||||||||||||
TrEMBL | Q3UER1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 230163 | ||||||||||||||||||||||
UniGene | Mm.218862 Mm.482116 Mm.486174 | ||||||||||||||||||||||
RefSeq | NM_144903 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS18176 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:87995 | ||||||||||||||||||||||
MGI Symbol | Aldob | ||||||||||||||||||||||
EMBL | AF403565 AF403566 AF403567 AK135385 AK149395 AK149598 AK167334 AK168600 AK168997 BC016435 BC022113 BC024056 BC024112 BC026577 BC030724 BC030725 BC034169 BC034171 BC034172 BC034173 BC036130 BC036131 BC036132 BC036133 CH466565 | ||||||||||||||||||||||
GenPept | AAH16435 AAH22113 AAH24056 AAH24112 AAH26577 AAH30724 AAH30725 AAH34169 AAH34171 AAH34172 AAH34173 AAH36130 AAH36131 AAH36132 AAH36133 AAL06323 BAE22514 BAE28850 BAE28983 BAE39436 BAE40467 BAE40796 EDL02311 | ||||||||||||||||||||||
RNA Seq Atlas | 230163 | ||||||||||||||||||||||