Version 5.4
Homo sapiens Gene: PDS5A
Summary
InnateDB Gene IDBG-14730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDS5A
Gene Name PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
Synonyms SCC-112; SCC112
Species Homo sapiens
Ensembl Gene ENSG00000121892
Encoded Proteins
IDBP-14732
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
IDBP-477911
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
IDBP-484187
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
IDBP-476324
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
IDBP-485157
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39822863-39977956
Strand Reverse strand
Band p14
Transcripts
ENST00000303538 ENSP00000303427
ENST00000507766
ENST00000507020 ENSP00000424510
ENST00000503696
ENST00000503396 ENSP00000426749
ENST00000513798 ENSP00000424531
ENST00000512643 ENSP00000425386
ENST00000503867
ENST00000508625
ENST00000506262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0008156 negative regulation of DNA replication
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029202
View Gene Order
ENSBTAG00000017809
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_150421
Cohesin Loading onto Chromatin pathway
REACT_1932
Mitotic Telophase/Cytokinesis pathway
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.331431 Hs.597130 Hs.603808 Hs.607202 Hs.624660 Hs.700053
RefSeq NM_001100399 NM_001100400 XM_005262652
HUGO
OMIM
CCDS CCDS47045 CCDS54759
HPRD 11537
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca