Mus musculus Gene: Tsc2
Summary
InnateDB Gene IDBG-147651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsc2
Gene Name tuberous sclerosis 2
Synonyms Nafld; Tcs2;
Species Mus musculus
Ensembl Gene ENSMUSG00000002496
Encoded Proteins
tuberous sclerosis 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103197:
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24595937-24632629
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000097373 ENSMUSP00000094986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0071889 14-3-3 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008104 protein localization
GO:0008285 negative regulation of cell proliferation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0030030 cell projection organization
GO:0030100 regulation of endocytosis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032007 negative regulation of TOR signaling
GO:0032320 positive regulation of Ras GTPase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043547 positive regulation of GTPase activity
GO:0045184 establishment of protein localization
GO:0045792 negative regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050918 positive chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0016020 membrane
GO:0030425 dendrite
GO:0030426 growth cone
GO:0033596 TSC1-TSC2 complex
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
FSH pathway
REACTOME
Signaling by FGFR in disease pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
mTOR signalling pathway
Inhibition of TSC complex formation by PKB pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Regulation of Rheb GTPase activity by AMPK pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
p53 signaling pathway pathway
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
Control of gene expression by vitamin d receptor [Biocarta view]
Mtor signaling pathway [Biocarta view]
PID NCI
Direct p53 effectors
mTOR signaling pathway
Validated targets of C-MYC transcriptional repression
LKB1 signaling events
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL Q3TP98 Q7TT21
UniProt Splice Variant
Entrez Gene 22084
UniGene
RefSeq NM_001039363 NM_001286716 NM_001286718 NM_011647 XM_006524044 XM_006524045 XM_006524046
OMIM
CCDS CCDS28486
HPRD
IMGT
MGI ID MGI:102548
MGI Symbol Tsc2
EMBL AC132367 AK164586 BC052449 BC060701
GenPept AAH52449 AAH60701 BAE37839
RNA Seq Atlas 22084