Mus musculus Gene: Ptk2
Summary
InnateDB Gene IDBG-148322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptk2
Gene Name PTK2 protein tyrosine kinase 2
Synonyms Fadk; FAK; FRNK; mKIAA4203; p125FAK
Species Mus musculus
Ensembl Gene ENSMUSG00000022607
Encoded Proteins
PTK2 protein tyrosine kinase 2
PTK2 protein tyrosine kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PTK2 induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signalling pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169398:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:73205105-73423191
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000110036 ENSMUSP00000105663
ENSMUST00000170939 ENSMUSP00000126764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 112 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008432 JUN kinase binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006928 cellular component movement
GO:0007172 signal complex assembly
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0040023 establishment of nucleus localization
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0050771 negative regulation of axonogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Apoptosis pathway
Hemostasis pathway
Netrin-1 signaling pathway
Signaling by VEGF pathway
EPHA-mediated growth cone collapse pathway
Apoptotic cleavage of cellular proteins pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
DCC mediated attractive signaling pathway
EPH-Ephrin signaling pathway
EPHB-mediated forward signaling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Developmental Biology pathway
p130Cas linkage to MAPK signaling for integrins pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
NCAM signaling for neurite out-growth pathway
Apoptotic execution phase pathway
KEGG
Axon guidance pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Regulation of actin cytoskeleton pathway
Small cell lung cancer pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL3 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSH pathway
Prolactin pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Signal regulatory protein (SIRP) family interactions pathway
Netrin mediated repulsion signals pathway
DCC mediated attractive signaling pathway
Netrin-1 signaling pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Cell-Cell communication pathway
EPHB-mediated forward signaling pathway
Signaling by VEGF pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Apoptosis pathway
Signal Transduction pathway
Immune System pathway
EPHA-mediated growth cone collapse pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Hemostasis pathway
KEGG
Regulation of actin cytoskeleton pathway
VEGF signaling pathway pathway
ErbB signaling pathway pathway
Axon guidance pathway
Leukocyte transendothelial migration pathway
Small cell lung cancer pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID NCI
Nongenotropic Androgen signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Caspase Cascade in Apoptosis
LPA receptor mediated events
CXCR4-mediated signaling events
Netrin-mediated signaling events
Integrins in angiogenesis
Internalization of ErbB1
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPHB forward signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.397095 Mm.470685
RefSeq NM_001130409 NM_007982 XM_006520420 XM_006520421 XM_006520422 XM_006520423 XM_006520432 XM_006520433
OMIM
CCDS CCDS37099 CCDS49631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas