Version 5.4
| Mus musculus Gene: Il1rl2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-148344.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Il1rl2 | ||||||||||||||||||
| Gene Name | interleukin 1 receptor-like 2 | ||||||||||||||||||
| Synonyms | AI481289; AW551444; IL-1Rrp2 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000070942 | ||||||||||||||||||
| Encoded Proteins |
interleukin 1 receptor-like 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
Il1rl2 binds members of the interleukin (IL)-1 family of cytokines that includes Il1f6, Il1f8 and Il1f9. Binding of these ligands to Il1rl2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Homo sapiens] IL1RL2 binds members of the interleukin (IL)-1 family of cytokines that includes IL1F6, IL1F8 and IL1F9. Binding of these ligands to IL1RL2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses. (Demonstrated in murine model)
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115598:
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:40324627-40365471 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | B | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9ERS7 | ||||||||||||||||||
| TrEMBL | Q149G7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 107527 | ||||||||||||||||||
| UniGene | Mm.155583 | ||||||||||||||||||
| RefSeq | NM_133193 XM_006495608 XM_006495609 XM_006495610 XM_006495611 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS14910 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1913107 | ||||||||||||||||||
| MGI Symbol | Il1rl2 | ||||||||||||||||||
| EMBL | AF284433 BC117797 CH466536 | ||||||||||||||||||
| GenPept | AAG21367 AAI17798 EDL14574 | ||||||||||||||||||
| RNA Seq Atlas | 107527 | ||||||||||||||||||