Homo sapiens Gene: IL1RL2
Summary
InnateDB Gene IDBG-64113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RL2
Gene Name interleukin 1 receptor-like 2
Synonyms IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2;
Species Homo sapiens
Ensembl Gene ENSG00000115598
Encoded Proteins
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
interleukin 1 receptor-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL1RL2 binds members of the interleukin (IL)-1 family of cytokines that includes IL1F6, IL1F8 and IL1F9. Binding of these ligands to IL1RL2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il1rl2 binds members of the interleukin (IL)-1 family of cytokines that includes Il1f6, Il1f8 and Il1f9. Binding of these ligands to Il1rl2 plays a critical role in the interface between innate and adaptive immunity, leading to the stimulation of dendritic and T helper cell responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:102186973-102240002
Strand Forward strand
Band q12.1
Transcripts
ENST00000264257 ENSP00000264257
ENST00000441515 ENSP00000413348
ENST00000421464 ENSP00000387611
ENST00000481806
ENST00000539491 ENSP00000442184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004908 interleukin-1 receptor activity
GO:0004909 interleukin-1, Type I, activating receptor activity
GO:0005515 protein binding
Biological Process
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0032755 positive regulation of interleukin-6 production
GO:0045087 innate immune response (InnateDB)
GO:0045582 positive regulation of T cell differentiation
GO:0050727 regulation of inflammatory response
GO:0070498 interleukin-1-mediated signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659863
RefSeq NM_003854 XM_005264035 XM_005264036
HUGO
OMIM
CCDS CCDS2056
HPRD 05150
IMGT
EMBL
GenPept
RNA Seq Atlas