InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atg5

Summary

InnateDB Gene

IDBG-148568.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atg5

Gene Name

autophagy related 5

Synonyms

2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l; AW319544; C88337; Paddy

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038160

Encoded Proteins

IDBP-148570

autophagy-related 5 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17921696

Atg12::Atg5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. Atg12::Atg5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

PMID 25650776

Atg5 knockout mice develop systemic and hepatic inflammation with high-fat diet and low-dose lipolysaccharide treatment.

PMID 26649827

Atg5 plays a unique role in protection against M. tuberculosis by preventing polymorphic mononuclear cell (PMN)-mediated immunopathology. Loss of Atg5 in PMNs can cause susceptibility to M. tuberculosis.

InnateDB Annotation from Orthologs

Summary

PMID 17709747

[Homo sapiens] ATG5 forms a conjugate with ATG12 to directly associate with DDX58 and MAVS and negatively regulate the antiviral IFN production pathway by mediating autophagy.

PMID 17921696

[Homo sapiens] ATG12::ATG5 conjugate is a key regulator of the autophagic process to eliminate pathogens such as Streptococcus, M. tuberculosis, Listeria, and herpesvirus. ATG12::ATG5 also associates with components of the RIG-I pathway to negatively regulate type I IFN response and promote RNA virus replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057663:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:44268358-44364291

Strand

Forward strand

Band

Transcripts

ENSMUST00000039286

ENSMUSP00000044769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0001974	blood vessel remodeling
GO:0002739	regulation of cytokine secretion involved in immune response
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0009620	response to fungus
GO:0031397	negative regulation of protein ubiquitination
GO:0039689	negative stranded viral RNA replication
GO:0042311	vasodilation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043687	post-translational protein modification
GO:0045087	innate immune response (InnateDB)
GO:0048840	otolith development
GO:0055015	ventricular cardiac muscle cell development
GO:0060047	heart contraction
GO:1902017	regulation of cilium assembly