InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prdm1

Summary

InnateDB Gene

IDBG-148617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdm1

Gene Name

PR domain containing 1, with ZNF domain

Synonyms

b2b1765Clo; Blimp-1; Blimp1; PRDI-BF1; ZNFPR1A1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038151

Encoded Proteins

IDBP-148619

PR domain containing 1, with ZNF domain

IDBP-270773

PR domain containing 1, with ZNF domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24477914

Prdm1 (Blimp1) modulates host defences by suppressing Ccl8-induced inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057657:
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:44437177-44528501

Strand

Reverse strand

Band

Transcripts

ENSMUST00000039174	ENSMUSP00000039248
ENSMUST00000105490	ENSMUSP00000101129
ENSMUST00000167340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	10 [view]
Protein-DNA	28 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0007281	germ cell development
GO:0009791	post-embryonic development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0030889	negative regulation of B cell proliferation
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032259	methylation
GO:0042462	eye photoreceptor cell development
GO:0045087	innate immune response (InnateDB)
GO:0045165	cell fate commitment
GO:0045579	positive regulation of B cell differentiation
GO:0060576	intestinal epithelial cell development
GO:0060707	trophoblast giant cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000057657

View Gene Order

ENSBTAG00000000816

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.4800

RefSeq

NM_007548 XM_006512502 XM_006512503 XM_006512505

OMIM

CCDS

CCDS23825

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas