InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gmps

Summary

InnateDB Gene

IDBG-148638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gmps

Gene Name

guanine monophosphate synthetase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027823

Encoded Proteins

IDBP-148640

guanine monophosphate synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163655:
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:63976106-64022579

Strand

Forward strand

Band

Transcripts

ENSMUST00000029405	ENSMUSP00000029405
ENSMUST00000163074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003921	GMP synthase activity
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524	ATP binding
GO:0016462	pyrophosphatase activity
GO:0016740	transferase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006529	asparagine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008033	tRNA processing
GO:0042493	response to drug