Version 5.4
Homo sapiens Gene: GMPS
Summary
InnateDB Gene IDBG-62407.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMPS
Gene Name guanine monphosphate synthetase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163655
Encoded Proteins
IDBP-62409
guanine monphosphate synthetase
IDBP-475140
guanine monphosphate synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:155870536-155944026
Strand Forward strand
Band q25.31
Transcripts
ENST00000295920 ENSP00000295920
ENST00000496455 ENSP00000419851
ENST00000476145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003921 GMP synthase activity
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016462 pyrophosphatase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006529 asparagine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0008033 tRNA processing
GO:0009113 purine nucleobase biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027823
View Gene Order
ENSBTAG00000013013
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591314 Hs.681195 Hs.735296
RefSeq NM_003875
HUGO
OMIM
CCDS CCDS46941
HPRD 10927
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca