Version 5.4
Homo sapiens Gene: KCNK10
Summary
InnateDB Gene IDBG-14892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK10
Gene Name potassium channel, subfamily K, member 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100433
Encoded Proteins
IDBP-14894
potassium channel, subfamily K, member 10
IDBP-14896
potassium channel, subfamily K, member 10
IDBP-14898
potassium channel, subfamily K, member 10
IDBP-590956
potassium channel, subfamily K, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:88180103-88326907
Strand Reverse strand
Band q31.3
Transcripts
ENST00000340700 ENSP00000343104
ENST00000319231 ENSP00000312811
ENST00000312350 ENSP00000310568
ENST00000556282 ENSP00000452587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0006810 transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033854
View Gene Order
ENSBTAG00000019355
Not yet available
Pathways
NETPATH
REACTOME
REACT_75819
TWIK related potassium channel (TREK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt P57789
TrEMBL
UniProt Splice Variant
Entrez Gene 54207
UniGene
RefSeq NM_138317 NM_021161 NM_138318
HUGO HGNC:6273
OMIM 605873
CCDS CCDS9881 CCDS9880 CCDS9882
HPRD 12061
IMGT
EMBL AF279890 AF385399 AF385400 AK313499 AK315263 AL049834 AL133279 BC075021 BC075022 CH471061 EU978938 EU978939 EU978940 EU978941
GenPept AAG15191 AAH75021 AAH75022 AAL95705 AAL95706 ACH86097 ACH86098 ACH86099 ACH86100 BAG36281 BAG37680 EAW81373 EAW81374 EAW81375
RNA Seq Atlas 54207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca