Homo sapiens Protein: KCNK10
Summary
InnateDB Protein IDBP-14898.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK10
Protein Name potassium channel, subfamily K, member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310568
InnateDB Gene IDBG-14892 (KCNK10)
Protein Structure
UniProt Annotation
Function Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR003976 Two pore domain potassium channel, TREK
IPR008074 Two pore domain potassium channel, TRAAK
IPR013099 Two pore domain potassium channel domain
PFAM PF07885
PRINTS PR01095
PR01333
PR01499
PR01691
PIRSF PIRSF038061
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57789
PhosphoSite PhosphoSite-P57789
TrEMBL
UniProt Splice Variant
Entrez Gene 54207
UniGene
RefSeq NP_612191
HUGO HGNC:6273
OMIM 605873
CCDS CCDS9882
HPRD 12061
IMGT
EMBL AF279890 AF385399 AF385400 AK313499 AK315263 AL049834 AL133279 BC075021 BC075022 CH471061 EU978938 EU978939 EU978940 EU978941
GenPept AAG15191 AAH75021 AAH75022 AAL95705 AAL95706 ACH86097 ACH86098 ACH86099 ACH86100 BAG36281 BAG37680 EAW81373 EAW81374 EAW81375