Version 5.4
Mus musculus Gene: Kdm1b
Summary
InnateDB Gene IDBG-149040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kdm1b
Gene Name lysine (K)-specific demethylase 1B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038080
Encoded Proteins
IDBP-149042
lysine (K)-specific demethylase 1B
IDBP-542064
lysine (K)-specific demethylase 1B
IDBP-534993
lysine (K)-specific demethylase 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165097:
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:47043499-47084613
Strand Forward strand
Band A5
Transcripts
ENSMUST00000037025 ENSMUSP00000038373
ENSMUST00000143868 ENSMUSP00000117793
ENSMUST00000143518 ENSMUSP00000114999
ENSMUST00000131120
ENSMUST00000128977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034649 histone demethylase activity (H3-monomethyl-K4 specific)
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0034720 histone H3-K4 demethylation
GO:0043046 DNA methylation involved in gamete generation
GO:0044030 regulation of DNA methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165097
View Gene Order
ENSBTAG00000014608
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_256030
HDMs demethylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8CIG3
TrEMBL D3Z353 Q3TE38
UniProt Splice Variant
Entrez Gene 218214
UniGene Mm.31259
RefSeq NM_172262 XM_006516913 XM_006516914 XM_006516915 XM_006516918 XM_006516919 XM_006516916 XM_006516917 XM_006516920
OMIM
CCDS CCDS26489
HPRD
IMGT
MGI ID MGI:2145261
MGI Symbol Kdm1b
EMBL AC096628 AC154171 AK028553 AK078920 AK169851 BC023917
GenPept AAH23917 BAC26005 BAC37460 BAE41410
RNA Seq Atlas 218214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca