Version 5.4
Homo sapiens Gene: KDM1B
Summary
InnateDB Gene IDBG-63966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM1B
Gene Name lysine (K)-specific demethylase 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165097
Encoded Proteins
IDBP-63968
lysine (K)-specific demethylase 1B
IDBP-363428
lysine (K)-specific demethylase 1B
IDBP-598049
lysine (K)-specific demethylase 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:18155329-18223853
Strand Forward strand
Band p22.3
Transcripts
ENST00000297792 ENSP00000297792
ENST00000449850 ENSP00000405669
ENST00000546309 ENSP00000442670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034649 histone demethylase activity (H3-monomethyl-K4 specific)
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0008033 tRNA processing
GO:0034720 histone H3-K4 demethylation
GO:0043046 DNA methylation involved in gamete generation
GO:0044030 regulation of DNA methylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038080
View Gene Order
ENSBTAG00000014608
Not yet available
Pathways
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8NB78
TrEMBL F2Z2A7 Q08EI0
UniProt Splice Variant
Entrez Gene 221656
UniGene Hs.709336
RefSeq NM_153042
HUGO HGNC:21577
OMIM 613081
CCDS CCDS34343
HPRD 18524
IMGT
EMBL AK091217 AK091428 AK125318 AL031774 AL589723 BC113093 CH471087 CR627410
GenPept AAI13094 BAC03612 BAC03663 BAC86124 CAH10499 CAM14159 CAM14160 CAM28216 CAM28217 EAW55401
RNA Seq Atlas 221656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca