Version 5.4
Mus musculus Gene: Id4
Summary
InnateDB Gene IDBG-149644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Id4
Gene Name inhibitor of DNA binding 4
Synonyms bHLHb27; Idb4
Species Mus musculus
Ensembl Gene ENSMUSG00000021379
Encoded Proteins
IDBP-149646
inhibitor of DNA binding 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172201:
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48261427-48264036
Strand Forward strand
Band A5
Transcripts
ENSMUST00000021810 ENSMUSP00000021810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007405 neuroblast proliferation
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0021766 hippocampus development
GO:0021895 cerebral cortex neuron differentiation
GO:0022010 central nervous system myelination
GO:0034613 cellular protein localization
GO:0045444 fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048712 negative regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000172201
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P41139
TrEMBL Q544D2
UniProt Splice Variant
Entrez Gene 15904
UniGene Mm.458006
RefSeq NM_031166
OMIM
CCDS CCDS26492
HPRD
IMGT
MGI ID MGI:99414
MGI Symbol Id4
EMBL AF077859 AJ001972 AK041164 X75018
GenPept AAD05213 BAC30845 CAA05120 CAA52926
RNA Seq Atlas 15904

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca