InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ID4

Summary

InnateDB Gene

IDBG-64059.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ID4

Gene Name

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Synonyms

bHLHb27; IDB4

Species

Homo sapiens

Ensembl Gene

ENSG00000172201

Encoded Proteins

IDBP-64061

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

IDBP-812264

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:19837386-19840684

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000378700	ENSP00000367972
ENST00000618493	ENSP00000480976

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0021766	hippocampus development
GO:0021895	cerebral cortex neuron differentiation
GO:0022010	central nervous system myelination
GO:0034613	cellular protein localization
GO:0045444	fat cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000021379

View Gene Order

Pathways

NETPATH

NetPath_5

ID pathway

REACTOME

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001546 XM_005249076

HUGO

OMIM

CCDS

CCDS4544

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas