InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vasp

Summary

InnateDB Gene

IDBG-149918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vasp

Gene Name

vasodilator-stimulated phosphoprotein

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030403

Encoded Proteins

IDBP-149922

vasodilator-stimulated phosphoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 14679200

[Homo sapiens] VASP is an important component of the cellular microfilament system that plays a major role in the regulation of serum response element (SRE)-dependent transcription. VASP activity is regulated by GMP-dependent protein kinase (G-kinase).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125753:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19256929-19271817

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032561	ENSMUSP00000032561
ENSMUST00000161488
ENSMUST00000162717

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030036	actin cytoskeleton organization
GO:0030838	positive regulation of actin filament polymerization
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005925	focal adhesion
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0070062	extracellular vesicular exosome