Version 5.4
Mus musculus Gene: Fosb
Summary
InnateDB Gene IDBG-150158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fosb
Gene Name FBJ osteosarcoma oncogene B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000003545
Encoded Proteins
IDBP-150160
FBJ osteosarcoma oncogene B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125740:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19302721-19310045
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000003640 ENSMUSP00000003640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007565 female pregnancy
GO:0009612 response to mechanical stimulus
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125740
View Gene Order
ENSBTAG00000008182
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt P13346
TrEMBL A2RSD4 I3PGL7 I3PGL8 I3PGL9
UniProt Splice Variant
Entrez Gene 14282
UniGene Mm.248335
RefSeq NM_008036 XM_006539543
OMIM
CCDS CCDS20897
HPRD
IMGT
MGI ID MGI:95575
MGI Symbol Fosb
EMBL AF093624 BC132064 BC137994 CH466639 HQ679939 X14897
GenPept AAD13196 AAI32065 AAI37995 AEX30307 AEX30308 AEX30309 CAA33026 EDL23136
RNA Seq Atlas 14282

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca