Version 5.4
Homo sapiens Gene: FOSB
Summary
InnateDB Gene IDBG-57590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOSB
Gene Name FBJ murine osteosarcoma viral oncogene homolog B
Synonyms AP-1; G0S3; GOS3; GOSB
Species Homo sapiens
Ensembl Gene ENSG00000125740
Encoded Proteins
IDBP-57592
FBJ murine osteosarcoma viral oncogene homolog B
IDBP-381940
FBJ murine osteosarcoma viral oncogene homolog B
IDBP-381941
FBJ murine osteosarcoma viral oncogene homolog B
IDBP-765834
IDBP-765810
IDBP-766244
IDBP-761031
IDBP-761243
IDBP-763862
IDBP-763637
IDBP-808105
FBJ murine osteosarcoma viral oncogene homolog B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45467995-45475179
Strand Forward strand
Band q13.32
Transcripts
ENST00000353609 ENSP00000245919
ENST00000443841 ENSP00000414177
ENST00000417353 ENSP00000407207
ENST00000586615 ENSP00000468207
ENST00000586113
ENST00000591858 ENSP00000466530
ENST00000592811 ENSP00000468482
ENST00000592436 ENSP00000465552
ENST00000590335 ENSP00000465068
ENST00000587358
ENST00000589593 ENSP00000465528
ENST00000585836 ENSP00000467497
ENST00000615753 ENSP00000485018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007565 female pregnancy
GO:0009612 response to mechanical stimulus
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003545
View Gene Order
ENSBTAG00000008182
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL K7EKA0 K7ERZ8 Q49AD7
UniProt Splice Variant
Entrez Gene 2354
UniGene Hs.590958 Hs.709124 Hs.717114
RefSeq NM_001114171 NM_006732 XM_005258691
HUGO HGNC:3797
OMIM 164772
CCDS CCDS12664 CCDS46113
HPRD 01270
IMGT
EMBL AC138128 BC040197
GenPept AAH40197
RNA Seq Atlas 2354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca