Version 5.4
Mus musculus Gene: Gpr50
Summary
InnateDB Gene IDBG-150845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr50
Gene Name G-protein-coupled receptor 50
Synonyms H9;
Species Mus musculus
Ensembl Gene ENSMUSG00000056380
Encoded Proteins
IDBP-150847
G-protein-coupled receptor 50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102195:
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:71663667-71669257
Strand Forward strand
Band A7.3
Transcripts
ENSMUST00000070449 ENSMUSP00000064608
ENSMUST00000144712
ENSMUST00000131554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008502 melatonin receptor activity
GO:0042802 identical protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000102195
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000005950
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O88495
TrEMBL
UniProt Splice Variant
Entrez Gene 14765
UniGene Mm.33336 Mm.474998
RefSeq NM_010340
OMIM
CCDS CCDS30181
HPRD
IMGT
MGI ID MGI:1333877
MGI Symbol Gpr50
EMBL AF065145 AK132272 AL840624 BC137982 CH466624
GenPept AAC21462 AAI37983 BAE21072 EDL26572
RNA Seq Atlas 14765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca