Homo sapiens Gene: GPR50
Summary
InnateDB Gene IDBG-88877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR50
Gene Name G protein-coupled receptor 50
Synonyms H9; Mel1c;
Species Homo sapiens
Ensembl Gene ENSG00000102195
Encoded Proteins
G protein-coupled receptor 50
G protein-coupled receptor 50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:151176653-151181465
Strand Forward strand
Band q28
Transcripts
ENST00000218316 ENSP00000218316
ENST00000617907 ENSP00000484496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008502 melatonin receptor activity
GO:0042802 identical protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9248
UniGene
RefSeq NM_004224
HUGO HGNC:4506
OMIM 300207
CCDS CCDS44012
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 9248