Mus musculus Gene: Fcnb | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-151717.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Fcnb | ||||||
Gene Name | ficolin B | ||||||
Synonyms | Fcn2 | ||||||
Species | Mus musculus | ||||||
Ensembl Gene | ENSMUSG00000026835 | ||||||
Encoded Proteins |
ficolin B
ficolin B
ficolin B
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
InnateDB Annotation | |||||||
Summary |
Fcnb is crucial for the induction of innate immunity against pneumococcal infection through the lectin complement pathway.
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InnateDB Annotation from Orthologs | |||||||
Summary |
[Homo sapiens] FCN1, as well as ficolins FCN2 and FCN3, in serum are associated with MBL-associated serine protease (MASP) to form a complex and this complex binds to carbohydrates present on the surface of a variety of Gram-positive and Gram-negative bacteria through ficolin, initiating complement activation via the lectin pathway.
[Homo sapiens] FCN1, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity.
[Homo sapiens] FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.
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Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085265:
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008] The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 2:28076378-28084885 | ||||||
Strand | Reverse strand | ||||||
Band | A3 | ||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||
NETPATH | |||||||
REACTOME |
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway
Complement cascade pathway
Immune System pathway
Lectin pathway of complement activation pathway
Initial triggering of complement pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Lectin pathway of complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway
Complement cascade pathway
Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway
Initial triggering of complement pathway
Immune System pathway
Creation of C4 and C2 activators pathway
Complement cascade pathway
Innate Immune System pathway
Lectin pathway of complement activation pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Mm.182935 | ||||||
RefSeq | NM_010190 | ||||||
OMIM | |||||||
CCDS | CCDS15832 | ||||||
HPRD | |||||||
IMGT | |||||||
MGI ID | |||||||
MGI Symbol | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||