Version 5.4
| Homo sapiens Gene: FCN1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-91827.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FCN1 | ||||||||||||||||||
| Gene Name | ficolin (collagen/fibrinogen domain containing) 1 | ||||||||||||||||||
| Synonyms | FCNM | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000085265 | ||||||||||||||||||
| Encoded Proteins |
ficolin (collagen/fibrinogen domain containing) 1
ficolin (collagen/fibrinogen domain containing) 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
FCN1, as well as ficolins FCN2 and FCN3, in serum are associated with MBL-associated serine protease (MASP) to form a complex and this complex binds to carbohydrates present on the surface of a variety of Gram-positive and Gram-negative bacteria through ficolin, initiating complement activation via the lectin pathway.
FCN1, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity.
FCN3 and PTX3 are soluble oligomeric pattern-recognition molecules that interact with each other and act synergistically to activate the lectin complement pathway.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Fcnb is crucial for the induction of innate immunity against pneumococcal infection through the lectin complement pathway.
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| Entrez Gene | |||||||||||||||||||
| Summary |
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008] The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 9:134905890-134917963 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q34.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Lectin pathway of complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway
Complement cascade pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O00602 | ||||||||||||||||||
| TrEMBL | Q92531 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2219 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_002003 XM_005263399 | ||||||||||||||||||
| HUGO | HGNC:3623 | ||||||||||||||||||
| OMIM | 601252 | ||||||||||||||||||
| CCDS | CCDS6985 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK314867 AL353611 BC020635 CH471090 D63394 D83920 S80990 | ||||||||||||||||||
| GenPept | AAB50706 AAH20635 BAA09707 BAA12120 BAG37382 CAH73911 EAW88137 | ||||||||||||||||||
| RNA Seq Atlas | 2219 | ||||||||||||||||||