InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: F11

Summary

InnateDB Gene

IDBG-152055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11

Gene Name

coagulation factor XI

Synonyms

1600027G01Rik; AI503996; Cf11; FXI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031645

Encoded Proteins

IDBP-152057

coagulation factor XI

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21807745

F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by Il8 or fMLP, highlighting the interplay between inflammation and coagulation.

InnateDB Annotation from Orthologs

Summary

PMID 21807745

[Homo sapiens] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by IL8 or fMLP, highlighting the interplay between inflammation and coagulation (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088926:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:45241170-45262031

Strand

Reverse strand

Band

B1.1

Transcripts

ENSMUST00000034064

ENSMUSP00000034064

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0070009	serine-type aminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0030193	regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0045087	innate immune response (InnateDB)
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000088926

View Gene Order

ENSBTAG00000003572

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_239392

Intrinsic Pathway pathway

REACT_235097

Formation of Fibrin Clot (Clotting Cascade) pathway

KEGG

mmu04610

Complement and coagulation cascades pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_326

Intrinsic Pathway pathway

REACT_2051

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_604

Hemostasis pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

Cross-References

SwissProt

Q91Y47

TrEMBL

UniProt Splice Variant

Entrez Gene

109821

UniGene

Mm.33326

RefSeq

NM_028066 XM_006509244 XM_006509245 XM_006509246

OMIM

CCDS

CCDS22274

HPRD

IMGT

MGI ID

MGI:99481

MGI Symbol

F11

EMBL

AF356627 AK005546 BC019485 CH466554

GenPept

AAH19485 AAK40233 BAB24114 EDL35542

RNA Seq Atlas

109821