Bos taurus Gene: F11 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-628594.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | F11 | ||||||||||||||
Gene Name | coagulation factor XI precursor | ||||||||||||||
Synonyms | FXI | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000003572 | ||||||||||||||
Encoded Proteins |
coagulation factor XI precursor
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by IL8 or fMLP, highlighting the interplay between inflammation and coagulation (Demonstrated in mouse)
[Mus musculus] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by Il8 or fMLP, highlighting the interplay between inflammation and coagulation.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088926:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 27:15350931-15370080 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Hemostasis pathway
Hemostasis pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
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KEGG |
Complement and coagulation cascades pathway
Complement and coagulation cascades pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | F1MUT4 Q2KJB4 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 407998 | ||||||||||||||
UniGene | Bt.29971 | ||||||||||||||
RefSeq | NM_001008665 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC105427 DAAA02060201 | ||||||||||||||
GenPept | AAI05428 | ||||||||||||||
RNA Seq Atlas | 407998 | ||||||||||||||